ABSTRACT
The upsurge of the severe acute respiratory syndrome-Coronavirus-2 (SARS-CoV-2) has turned into a global health disaster. Many remodeled medications were suggested for treatment in the early stages of this pandemic, but these dosages afterward came across with distinct offshoots. Thus, these consequences compelled the scientists to develop new drugs using various antiviral, antiinflammatory, antibacterial, and phytochemical compounds. A handful of drugs have been scrutinized in silico, in vitro, plus through human trials such as anti-SARS-CoV-2 agents and made available as various databases by various scientific communities. The SARS-CoV-2 pandemic databases are designed to allay difficulties associated with this scenario. Some of the popular databases are GESS (global evaluation of SARS-CoV-2/HCoV-19 sequences) which gives a thorough study of data based on tenfold of thousands of complete coverage and quality of SARS-CoV-2 genomes, CORona Drug InTERactions (CORDITE) database for SARS-CoV-2 which profoundly combines the understanding of potential drugs and make it available for scientists and medicos. SARSCOVIDB set one’s sights to merge all differential gene expression data, at mRNA and protein levels, helping to accelerate analysis and research on the molecular impact of covid-19. This chapter aims to provide a piece of complete information about the SARS-CoV-2 virus databases, potentially available drugs, and virtual screening methods. And also provides a different webserver to reach out for information related to the COVID-19 pandemic and its future. © 2022 Elsevier Inc. All rights reserved.
ABSTRACT
The outbreak and rapid spread of novel Coronavirus SARS-CoV-2 has resulted in global pandemic. The purpose of this work is to provide an ethnopharmacological overview of selected medicinal plants having antiviral activity along with their applications to treat COVID-19 related symptoms based on fragmented literature. Hundreds of published research articles were screened and reviewed using online search engines such as PubMed, PMC and Google Scholar with relevant keywords related to coronavirus, antiviral medicinal plants, phytochemical compounds, cough and fever. A total of 12 plants having antiviral activity against a number of viruses were documented with their probable mechanism of action. Most of the studied plants and their compounds were also reported to have other therapeutic potentials and were used to boost immunity, treat cough, fever, tiredness, difficulty in breathing and diarrhoea, which are common symptoms of COVID-19 infections as per World Health Organization. This review hopefully opens a new horizon in the development of antiviral drug against novel coronavirus COVID-19.